- Title
- Chinese herbal medicine formula for acute asthma: A multi-center, randomized, double-blind, proof-of-concept trial
- Creator
- Zhang, Hong Ping; Wang, Lei; Wang, Gang; Wang, Zhen; Xu, Xian Rong; Zhou, Xian Mei; Liu, Gang; He, Lv Yuan; Wang, Jun; Hsu, Alan; Li, Wei Min
- Relation
- Respiratory Medicine Vol. 140, p. 42-49
- Publisher Link
- http://dx.doi.org/10.1016/j.rmed.2018.05.014
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2018
- Description
- Background: Despite advances in asthma management, exacerbations constitute a significant health economic burden. Objective: To observe the efficacy and safety of Chinese herbal medicine formula entitled PingchuanYiqi (PCYQ) granule, on acute asthma and to explore its possible mechanism. Materials and methods: This proof-of-concept study consisted of a randomized, double-blind, placebo-controlled trial in patients with acute asthma (n = 300). Participants with acute mild-to-moderate asthma recruited from seven centers in China were randomly assigned to receive PCYQ or placebo. The primary outcomes were PEF (L/min) and total asthma symptom scores. Furthermore, a panel of cytokines including serum IL-4, IL-5, IL-6, IL-8, IL-1β, IL-17A, IFN-α, IFN-β, IFN-γ, CRP, CCL-5, IP-10, and PGD2 levels was detected using ELISA. Results: The PCYQ (n = 139) significantly improved the morning PEF on day 4 (349.73 ± 93.92 vs. 313.56 ± 92.91 L/min, P = 0.004) and day 7 (360.42 ± 94.39 vs. 329.52 ± 95.97 L/min, P = 0.023), and the evening PEF on day 4 (352.65 ± 95.47 vs. 320.58 ± 95.30 L/min, P = 0.012) and day 7 (360.42 ± 94.39 vs. 336.86 ± 95.59 L/min, P = 0.029) in comparison with the placebo (n = 143). The PCYQ also improved the clinical symptoms scores and reduced the puffs of short-acting β2-agonist (all P < 0.05). Furthermore, the PCYQ statistically reduced IL-5, IL-8, IL-1β and PGD2 in serum. Conclusion: The PCYQ as the Chinese herbal medicine formula significantly improves lung function and symptoms of acute asthma, and reduces SABA dosage possibly via decrease of inflammatory biomarkers such as IL-5, IL-8, IL-1β and PGD2.
- Subject
- chinese herbal medicine formula; acute asthma; randomized controlled trial; inflammatory cytokines; proof-of-concept; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1447209
- Identifier
- uon:43085
- Identifier
- ISSN:0954-6111
- Language
- eng
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