- Title
- The "unnatural" history of colorectal cancer in Lynch syndrome: lessons from colonoscopy surveillance
- Creator
- Ahadova, Aysel; Seppälä, Toni T.; Laghi, Luigi; Dominguez-Valentin, Mev; Capella, Gabriel; Macrae, Finlay; Scott, Rodney; Hüneburg, Robert; Nattermann, Jacob; Hoffmeister, Michael; Brenner, Hermann; Bläker, Hendrik; Engel, Christoph; von Knebel Doeberitz, Magnus; Sampson, Julien R.; Vasen, Hans; Mecklin, Jukka-Pekka; Møller, Pal; Kloor, Matthias; Gallon, Richard; Burn, John; Holinski-Feder, Elke; Steinke-Lange, Verena; Möslein, Gabriela; Nielsen, Maartje; ten Broeke, Sanne W.
- Relation
- International Journal of Cancer Vol. 148, Issue 4, p. 800-811
- Publisher Link
- http://dx.doi.org/10.1002/ijc.33224
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2021
- Description
- Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alongside with hypotheses addressing colonoscopy quality and pace of progression from adenoma to cancer, we discuss the role of alternative precursors and immune system in LS-associated CRC. We also identify gaps in current knowledge and make suggestions for future studies aiming at improved CRC prevention for LS individuals.
- Subject
- colonoscopy surveillance; colorectal cancer; incident cancer risk; lynch syndrome; microsatellite instability; mismatch repair deficiency; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1446086
- Identifier
- uon:42759
- Identifier
- ISSN:0020-7136
- Rights
- © 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Language
- eng
- Full Text
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