- Title
- The effect of a novel low-volume aerobic exercise intervention on liver fat in type 2 diabetes: A randomized controlled trial
- Creator
- Sabag, Angelo; Way, Kimberley L.; Twigg, Stephen M.; Johnson, Nathan A.; Sultana, Rachelle N.; Keating, Shelley E.; Gerofi, James A.; Chuter, Vivienne H.; Byrne, Nuala M.; Baker, Michael K.; George, Jacob; Caterson, Ian D.
- Relation
- Diabetes Care Vol. 43, Issue 10, p. 2371-2378
- Publisher Link
- http://dx.doi.org/10.2337/dc19-2523
- Publisher
- American Diabetes Association
- Resource Type
- journal article
- Date
- 2020
- Description
- Objective: The aim of this study was to examine the effect of a novel low-volume high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), or placebo (PLA) intervention on liver fat, glycemia, and cardiorespiratory fitness using a randomized placebo-controlled design. Research Design and Methods: Thirty-five inactive adults (age 54.6 ± 1.4 years, 54% male; BMI 35.9 ± 0.9 kg/m2) with obesity and type 2 diabetes were randomized to 12 weeks of supervised MICT (n = 12) at 60% VO2peak for 45 min, 3 days/week; HIIT (n = 12) at 90% VO2peak for 4 min, 3 days/week; or PLA (n = 11). Liver fat percentage was quantified through proton MRS. Results: Liver fat reduced in MICT (−0.9 ± 0.7%) and HIIT (−1.7 ± 1.1%) but increased in PLA (1.2 ± 0.5%) (P = 0.046). HbA1c improved in MICT (−0.3 ± 0.3%) and HIIT (−0.3 ± 0.3%) but not in PLA (0.5 ± 0.2%) (P = 0.014). Cardiorespiratory fitness improved in MICT (2.3 ± 1.2 mL/kg/min) and HIIT (1.1 ± 0.5 mL/kg/min) but not in PLA (−1.5 ± 0.9 mL/kg/min) (P = 0.006). Conclusions: MICT or a low-volume HIIT approach involving 12 min of weekly high-intensity aerobic exercise may improve liver fat, glycemia, and cardiorespiratory fitness in people with type 2 diabetes in the absence of weight loss. Further studies are required to elucidate the relationship between exercise-induced reductions in liver fat and improvements in glycemia.
- Subject
- adipose tissue; adiposity; Australia; diabetes mellitus, Type 2; exercise; liver; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1445789
- Identifier
- uon:42669
- Identifier
- ISSN:0149-5992
- Language
- eng
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