- Title
- Long-chain omega-3 polyunsaturated fatty acids and cognitive decline in non-demented adults: A systematic review and meta-analysis
- Creator
- Alex, Anu; Abbott, Kylie A.; McEvoy, Mark; Schofield, Peter W.; Garg, Manohar L.
- Relation
- Nutrition Reviews Vol. 78, Issue 7, p. 563-578
- Publisher Link
- http://dx.doi.org/10.1093/nutrit/nuz073
- Publisher
- Oxford University Press
- Resource Type
- journal article
- Date
- 2020
- Description
- Context: Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs) are widely considered as nootropic agents that may be beneficial in reversing cognitive impairment. Objective: The present systematic review of randomized controlled trials was conducted to determine the changes in cognitive function after intervention with LCn-3PUFA supplementation in non-demented adults, including those with mild cognitive impairment. Data Sources: Five databases (MEDLINE, CINAHL, Scopus, EMBASE, and the Cochrane Library) were searched systematically along with reference lists of selected articles. Study Selection: Studies were eligible for inclusion if they measured the effect of LCn-3PUFA supplementation on cognition in non-demented adults. Data Extraction: A total of 787 records were screened, of which 25 studies were eligible for inclusion. Treatment effects were summarized as global cognitive function for primary outcome and measured using the Mini-Mental State Examination and individual cognitive domains for secondary outcome. The pooled effect sizes were estimated using Hedge's g and random-effects modeling. Data Analysis: Results from randomized controlled trials indicate that LCn-3PUFAs have no effect on global cognitive function (Hedge's g = 0.02; 95% confidence interval, -0.12 to 0.154), and among the specific cognitive domains, only memory function showed a mild benefit (Hedge's g = 0.31; P = 0.003; z = 2.945). Conclusion: The existing literature suggests that LCn-3PUFA supplementation could provide a mild benefit in improving memory function in non-demented older adults.
- Subject
- cognition; docosahexaenoic acid; long-chain omega-3 polyunsaturated fatty acids; non-demented adults; adults; systematic review
- Identifier
- http://hdl.handle.net/1959.13/1442690
- Identifier
- uon:41765
- Identifier
- ISSN:0029-6643
- Language
- eng
- Reviewed
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