- Title
- Optimising low-dose methotrexate for rheumatoid arthritis—a review
- Creator
- Lucas, Catherine J.; Dimmitt, Simon B.; Martin, Jennifer H.
- Relation
- British Journal of Clinical Pharmacology Vol. 85, Issue 10, p. 2228-2234
- Publisher Link
- http://dx.doi.org/10.1111/bcp.14057
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2019
- Description
- Methotrexate at low doses (5-25 mg/week) is first-line therapy for rheumatoid arthritis. However, there is inter- and intrapatient variability in response, with contribution of variability in concentrations of active polyglutamate metabolites, associated with clinical efficacy and toxicity. Prescribing remains heterogeneous across population groups, disease states and regimens. This review examines current knowledge of dose-response of oral methotrexate in the setting of rheumatoid arthritis, and how this could help inform dosage regimens.
- Subject
- clinical pharmacolaogy; methotrexate; pharmacodynamics; pharmacokinetics; prescribing; rheumatoid arthritis
- Identifier
- http://hdl.handle.net/1959.13/1442554
- Identifier
- uon:41720
- Identifier
- ISSN:0306-5251
- Language
- eng
- Reviewed
- Hits: 368
- Visitors: 366
- Downloads: 0
| Thumbnail | File | Description | Size | Format |
|---|