- Title
- Decreased Intracranial Pressure Elevation and Cerebrospinal Fluid Outflow Resistance: A Potential Mechanism of Hypothermia Cerebroprotection Following Experimental Stroke
- Creator
- Omileke, Daniel; Bothwell, Steven W.; Pepperall, Debbie; Beard, Daniel J.; Coupland, Kirsten; Patabendige, Adjanie; Spratt, Neil J.
- Relation
- NHMRC.GNT1110629 http://purl.org/au-research/grants/nhmrc/1110629
- Relation
- Brain Sciences Vol. 11, Issue 12
- Publisher Link
- http://dx.doi.org/10.3390/brainsci11121589
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2021
- Description
- Background: Elevated intracranial pressure (ICP) occurs 18–24 h after ischaemic stroke and is implicated as a potential cause of early neurological deterioration. Increased resistance to cerebrospinal fluid (CSF) outflow after ischaemic stroke is a proposed mechanism for ICP elevation. Ultra-short duration hypothermia prevents ICP elevation 24 h post-stroke in rats. We aimed to determine whether hypothermia would reduce CSF outflow resistance post-stroke. Methods: Transient middle cerebral artery occlusion was performed, followed by gradual cooling to 33 °C. At 18 h post-stroke, CSF outflow resistance was measured using a steady-state infusion method. Results: Hypothermia to 33 °C prevented ICP elevation 18 h post-stroke (hypothermia ∆ICP = 0.8 ± 3.6 mmHg vs. normothermia ∆ICP = 4.4 ± 2.0 mmHg, p = 0.04) and reduced infarct volume 24 h post-stroke (hypothermia = 78.6 ± 21.3 mm3 vs. normothermia = 108.1 ± 17.8 mm3; p = 0.01). Hypothermia to 33 °C did not result in a significant reduction in CSF outflow resistance compared with normothermia controls (0.32 ± 0.36 mmHg/µL/min vs. 1.07 ± 0.99 mmHg/µL/min, p = 0.06). Conclusions: Hypothermia treatment was protective in terms of ICP rise prevention, infarct volume reduction, and may be implicated in CSF outflow resistance post-stroke. Further investigations are warranted to elucidate the mechanisms of ICP elevation and hypothermia treatment.
- Subject
- hypothermia; cerebrospinal fluid; outflow resistance; ischaemia; intracranial pressure; stroke; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1438572
- Identifier
- uon:40646
- Identifier
- ISSN:2076-3425
- Rights
- © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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