- Title
- The effect of optic nerve section on form deprivation myopia in the guinea pig
- Creator
- McFadden, Sally A.; Wildsoet, Christine
- Relation
- Journal of Comparative Neurology Vol. 528, Issue 17, p. 2874-2887
- Publisher Link
- http://dx.doi.org/10.1002/cne.24961
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2020
- Description
- Myopia is induced when a growing eye wears a diffuser that deprives it of detailed spatial vision (form deprivation, FD). In chickens with optic nerve section (ONS), FD myopia still occurs, suggesting that the signals underlying myopia reside within the eye. As avian eyes differ from mammals, we asked whether local mechanisms also underlie FD myopia in a mammalian model. Young guinea pigs underwent either sham surgery followed by FD (SHAM + FD, n = 7); or ONS followed by FD (ONS + FD, n = 7); or ONS without FD (ONS, n = 9). FD was initiated 3 days after surgery with a diffuser that was worn on the surgically treated eye for 14 days. Animals with ONS + FD developed −8.9 D of relative myopia and elongated by 135 μm more than in their untreated eyes after 2 weeks of FD. These changes were significantly greater than those in SHAM + FD animals (−5.5 D and 40 μm of elongation after 14 days of FD), and reflected exaggerated elongation of the posterior vitreous chamber. The myopia reversed when FD was discontinued, despite ONS, but eyes did not recover back to normal (30 days after surgery, ONS + FD eyes still retained −3 D of relative myopia when SHAM+FD animals had returned to normal). No long-term residual myopia was present after ONS alone, ruling out a surgical artifact. Although the gross mechanism signaling myopic ocular growth and its recovery in the young mammalian eye does not require an intact optic nerve, its fine-tuning is disrupted by ONS.
- Subject
- form deprivation; myopia; optic nerve; RRID:Nil
- Identifier
- http://hdl.handle.net/1959.13/1434892
- Identifier
- uon:39541
- Identifier
- ISSN:0021-9967
- Rights
- This is the peer reviewed version of the following article: McFadden, Sally A.; Wildsoet, Christine. The effect of optic nerve section on form deprivation myopia in the guinea pig”. Journal of Comparative Neurology Vol. 528, Issue 17, p. 2874-2887 (2020), which has been published in final form at http://dx.doi.org/10.1002/cne.24961. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
- Language
- eng
- Full Text
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