- Title
- Curcumin-loaded niosomes downregulate mRNA expression of pro-inflammatory markers involved in asthma: an in vitro study
- Creator
- Wong, Jin-Ying; Ng, Zhao Yin; Hsu, Alan; Hansbro, Nicole G.; Wark, Peter; Bebawy, Mary; Hansbro, Philip Michael; Dua, Kamal; Chellappan, Dinesh Kumar; Mehta, Meenu; Shukla, Shakti D.; Panneerselvam, Jithendra; Madheswaran, Thiagarajan; Gupta, Gaurav; Negi, Poonam; Kumar, Pradeep; Pillay, Viness
- Relation
- Nanomedicine Vol. 15, Issue 30, p. 2955-2970
- Publisher Link
- http://dx.doi.org/10.2217/nnm-2020-0260
- Publisher
- Future Medicine Ltd
- Resource Type
- journal article
- Date
- 2020
- Description
- Aim: In this study, curcumin was encapsulated in niosomes (Nio-Curc) to increase its effectiveness for the treatment of asthma. Materials & methods: The formulation underwent various physicochemical characterization experiments, an in vitro release study, molecular simulations and was evaluated for in vitro anti-inflammatory activity. Results: Results showed that Nio-Curc had a mean particle size of 284.93 ± 14.27 nm, zeta potential of -46.93 and encapsulation efficacy of 99.62%, which demonstrates optimized physicochemical characteristics. Curcumin release in vitro could be sustained for up to 24 h. Additionally, Nio-Curc effectively reduced mRNA transcript expression of pro-inflammatory markers; IL-6, IL-8, IL-1β and TNF-a in immortalized human airway basal cell line (BCi-NS1.1). Conclusion: In this study, we have demonstrated that Nio-Curc mitigated the mRNA expression of pro-inflammatory markers in an in vitro study, which could be applied to treatment of asthma with further studies.
- Subject
- asthma; curcumin; molecular modeling; niosomes; pro-inflammatory markers
- Identifier
- http://hdl.handle.net/1959.13/1432509
- Identifier
- uon:39066
- Identifier
- ISSN:1743-5889
- Language
- eng
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