- Title
- Clinical and inflammatory features of exacerbation-prone asthma: a cross-sectional study using multidimensional assessment
- Creator
- Feng, Min; Zhang, Xin; Wang, Lei; Li, Wei Min; Wang, Gang; Gibson, Peter G.; Wu, Wen Wen; Chen, Zhi Hong; Oliver, Brian G.; McDonald, Vanessa M.; Zhang, Hong Ping; Xie, Min; Qin, Ling; Zhang, Jie
- Relation
- Respiration Vol. 99, Issue 12, p. 1109-1121
- Publisher Link
- http://dx.doi.org/10.1159/000510793
- Publisher
- S. Karger AG
- Resource Type
- journal article
- Date
- 2020
- Description
- Background: Reducing asthma exacerbations is a major target of current clinical guidelines, but identifying features of exacerbation-prone asthma (EPA) using multidimensional assessment (MDA) is lacking. Objective: To systemically explore the clinical and inflammatory features of adults with EPA in a Chinese population. Methods: We designed a cross-sectional study using the Severe Asthma Web-based Database from the Australasian Severe Asthma Network (ASAN). Eligible Chinese adults with asthma (n = 546) were assessed using MDA. We stratified patients based on exacerbation frequency: none, few (1 or 2), and exacerbation prone (≥3). Univariate and multivariable negative binomial regression analyses were performed to investigate features associated with the frequency of exacerbations. Results: Of 546 participants, 61.9% had no exacerbations (n = 338), 29.6% had few exacerbations (n = 162), and 8.4% were exacerbation prone (n = 46) within the preceding year. EPA patients were characterized by elevated blood and sputum eosinophils but less atopy, with more controller therapies but worse asthma control and quality of life (all p < 0.05). In multivariable models, blood and sputum eosinophils (adjusted rate ratio = 2.23, 95% confidence interval = [1.26, 3.84] and 1.67 [1.27, 2.21], respectively), FEV1 (0.90 [0.84, 0.96]), bronchodilator responsiveness (1.16 [1.05, 1.27]), COPD (2.22 [1.41, 3.51]), bronchiectasis (2.87 [1.69, 4.89]), anxiety (2.56 [1.10, 5.95]), and depression (1.94 [1.20, 3.13]) were found. Further, upper respiratory tract infection (1.83 [1.32, 2.54]) and food allergy (1.67 [1.23, 2.25]) were at high risk of asthma symptom triggers. Conclusion: EPA is a clinically recognizable phenotype associated with several recognizable traits that could be addressed by targeted treatment.
- Subject
- bronchodilator reversibility; eosinophils; exacerbation-prone asthma; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1430191
- Identifier
- uon:38811
- Identifier
- ISSN:1423-0356
- Language
- eng
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