- Title
- Circulating RNA differences between patients with stable and progressive idiopathic pulmonary fibrosis
- Creator
- Clynick, Britt; Jo, Helen E.; Keir, Gregory J.; Cooper, Wendy A.; Mahar, Annabelle M.; Ellis, Samantha; Goh, Nicole S.; Baltic, Svetlana; Rya, Marisa; Tan, Dino B. A.; Moodley, Yuben P.; Corte, Tamera J.; Glaspole, Ian N.; Grainge, Christopher; Hopkins, Peter M. A.; Reynolds, Paul N.; Chapman, Sally; Walters, E. Haydn; Zappala, Christopher
- Relation
- NHMRC.APP1066128 http://purl.org/au-research/grants/nhmrc/1066128
- Relation
- European Respiratory Journal Vol. 56, Issue 3, no. 1902058
- Publisher Link
- http://dx.doi.org/10.1183/13993003.02058-2019
- Publisher
- European Respiratory Society
- Resource Type
- journal article
- Date
- 2020
- Description
- Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterised by progressive decline in pulmonary function. The rate of decline can vary, with some patients remaining stable over longer periods of time and others rapidly progressing [1]. The variable progression of this disease makes it difficult to elucidate pathogenic pathways involved in the initiation and progression of IPF. Advances in high-throughput gene-expression analyses have led to improvements in our understanding of disease biology and prognostic gene signatures. We hypothesise that IPF has a unique circulatory transcriptional profile compared to healthy controls, with additional differences between stable and progressive disease likely related to disease pathogenesis.
- Subject
- idiopathic pulmonary fibrosis (IPF); disease pathogenesis; pathogenic pathways; prognostic gene signatures; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1429908
- Identifier
- uon:38777
- Identifier
- ISSN:0903-1936
- Language
- eng
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