- Title
- Venom pharmacometrics: pharmacokinetics and pharmacodynamics of red-bellied black snake venom
- Creator
- Isbister, Geoffrey
- Resource Type
- dataset
- Date
- 2021
- Description
- Associated raw data for the manuscript "Pharmacokinetics and Pharmacodynamics of red-bellied black snake venom". timed venom and creatine kinase concentrations from definite red-bellied black snake bites in 114 patients. The data is in an Excel, but prepared as a datafile for NONMEM - this dataset presented in 1 CSV file, file size. Dataset is compiled from patient characteristics and serial blood samples (timed venom concentrations and CK concentrations, pre- and post- antivenom) from 114 patients (median age 41, 2-90y; 80 male) extracted from the Australian Snakebite Project database. Patients were categorised into three groups based on peak CK concentrations [no myotoxicity (<1000 U/L), mild (1000-10,000 U/L) and severe (>10,000 U/L)]. The odds of (mild or severe) myotoxicity was lower in patients that received early antivenom (within 6 hours post-bite) compared to those that received late or no antivenom (odd ratio was 0.186; 95% confidence interval, 0.052 – 0.664). A population pharmacokinetic-pharmacodynamic (PKPD) model was developed to describe the relationship between the time course of venom (a mixture of toxins) and effect (elevated CK). In addition, a kinetic-pharmacodynamic (KPD) model was developed to describe the relationship between time course of a theoretical toxin and effect. Model development and parameter estimation was performed using NONMEM v7.3. No single set of parameter values from either the PKPD or KPD models were found that could accurately describe the time course of different levels of severity of myotoxicity. The predicted theoretical toxin half-life from the KPD model was 11 ± 3.9 hours compared to the half-life of venom of 5.3 ± 0.36 hours. This indicates that the putative causative toxin’s concentration-time profile does not parallel that of venom.
- Subject
- pharmacokinetics; venom; pharmacodynamics; creatinine; snake envenoming; myotoxicity; MEDICAL AND HEALTH SCIENCES
- Identifier
- uon:38297
- Identifier
- http://hdl.handle.net/1959.13/1425704
- Publisher Link
- http://dx.doi.org/10.25817/4j9m-yt03
- Rights
- http://opendatacommons.org/licenses/pddl/1.0/
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Data File | 207 KB | Comma-Separated Values File | View Details Download |