- Title
- Central vein sign for multiple sclerosis: a systematic review and meta-analysis
- Creator
- Bhandari, A.; Xiang, H.; Lechner-Scott, J.; Agzarian, M.
- Relation
- Clinical Radiology Vol. 75, Issue 6, p. 479.e9-479.e15
- Publisher Link
- http://dx.doi.org/10.1016/j.crad.2020.01.011
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2020
- Description
- Aims: To systematically review the diagnostic value of the central vein sign (CVS) in multiple sclerosis (MS) and to meta-analyse the proportion of positive lesions for CVS needed to distinguish MS from non-MS mimics. Materials and Methods: A literature review was performed and a proportion meta-analysis was performed to examine the proportion of the CVS in MS lesions. Studies reporting a threshold of the CVS containing lesions with 100% diagnostic accuracy were included in the meta-analysis. This was compared to MS mimics in order to establish the discriminative value of the CVS. Results: The CVS was found to be viable at lower field strengths (3 T and 1.5 T) and automated analysis is currently less accurate than manual counting. Five studies were included for the proportional meta-analysis. From the analysis, a proportion of 45% of lesions having the CVS was suggested given that the findings that the weighted proportion was 46.4% (95% confidence interval [CI]: of 40.3%–52.6%) with low heterogeneity (I2 = 0.0%; p=0.5). Conclusion: Although the CVS is a clinically relevant and viable sign, further work is needed to integrate this into the existing diagnostic criteria. As manual determination is a time-consuming process, the development of automated methods will be beneficial. With improvements in computational imaging techniques, the CVS will have an important role in the diagnosis and differentiation of MS.
- Subject
- multiple sclerosis; systematic review; meta-analysis; central vein sign
- Identifier
- http://hdl.handle.net/1959.13/1425088
- Identifier
- uon:38205
- Identifier
- ISSN:0009-9260
- Language
- eng
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