- Title
- The role of growth factor receptors in viral infections: an opportunity for drug repurposing against emerging viral diseases such as COVID-19?
- Creator
- Hondermarck, Hubert; Bartlett, Nathan W.; Nurcombe, Victor
- Relation
- FASEB BioAdvances Vol. 2, Issue 5, p. 296-303
- Publisher Link
- http://dx.doi.org/10.1096/fba.2020-00015
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2020
- Description
- Growth factor receptors are known to be involved in the process of viral infection. Many viruses not only use growth factor receptors to physically attach to the cell surface and internalize, but also divert receptor tyrosine kinase signaling in order to replicate. Thus, repurposing drugs that have initially been developed to target growth factor receptors and their signaling in cancer may prove to be a fast track to effective therapies against emerging new viral infections, including the coronavirus disease 19 (COVID-19).
- Subject
- cancer drugs; COVID‐19; growth factors; heparan sulfate; heparin; inhibitors; SARS‐CoV‐2; tyrosine kinase; virus
- Identifier
- http://hdl.handle.net/1959.13/1421157
- Identifier
- uon:37697
- Identifier
- ISSN:2573-9832
- Rights
- © 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Language
- eng
- Full Text
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