- Title
- Colorectal carcinoma in the course of inflammatory bowel diseases
- Creator
- Hnatyszyn, Andrzej; Hryhorowicz, Szymon; Kaczmarek-Rys, Marta; Lis, Emilia; Slomski, Ryszard; Scott, Rodney J.; Plawski, Andrzej
- Relation
- Hereditary Cancer in Clinical Practice Vol. 17, no. 18
- Publisher Link
- http://dx.doi.org/10.1186/s13053-019-0118-4
- Publisher
- BioMed Central
- Resource Type
- journal article
- Date
- 2019
- Description
- Background: Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are the most prevalent diseases of the digestive system, and their association is unequivocal. A long-standing inflammatory process is one of the causes of sporadic as well as inherited cancers as it impacts on malignant transformation in a wide variety of neoplastic diseases, including colorectal cancer. Methods: An extensive publication search was performed in Medline and PubMed database. The keywords: colorectal carcinoma, inflammation, Crohn disease, ulcerative colitis and inflammatory bowel disease were used. Results: The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and toll like receptor (TLR) signaling pathways are clearly involved in the inflammatory process and are therefore implicated in the transformation of normal colonic mucosa to premalignant and malignant disease. Focal sites of inflammation could significantly increase the risk of initiation and development of cancer. Altered inflammatory activity is likely to be a result of either a disturbance of intestinal bacterial flora or an inadequate cellular response to it. Additionally, increasing the level of inflammation-related factors may also interfere with the control of cellular proliferation. Conclusions: This review shows an overview of the genetic and environmental factors that appear to influence both the occurrence of IBD and CRC with particular reference to NOD2 and TLRs as well as pro- and anti-inflammatory cytokines associated with tumor initiation and progression (encompassing both tumor invasion and metastases), as they constitute potential targets for therapeutic intervention.
- Subject
- colorectal cancer; inflammation; crohn disease; ulcerative colitis; IBD; inflammatory bowel disease
- Identifier
- http://hdl.handle.net/1959.13/1414940
- Identifier
- uon:36834
- Identifier
- ISSN:1731-2302
- Rights
- This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Language
- eng
- Full Text
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