- Title
- The Nepean Dyspepsia Index is a valid instrument for measuring quality-of-life in functional dyspepsia
- Creator
- Jones, Michael P.; Sato, Yuri A.; Talley, Nicholas J.
- Relation
- European Journal of Gastroenterology and Hepatology Vol. 31, Issue 3, p. 329-333
- Publisher Link
- http://dx.doi.org/10.1097/MEG.0000000000001314
- Resource Type
- journal article
- Date
- 2019
- Description
- Background: The Nepean Dyspepsia Index (NDI) has been in widespread use since its publication in 1999 and the addition of a short form in 2001. The NDI was one of the first disease-specific quality-of-life instruments created for functional dyspepsia (FD). However, its psychometric properties have never been validated in an independent sample. Aim: This study aimed to evaluate the validity and reliability of the NDI in an a-priori driven approach in an independent population. Patients and methods: In 289 individuals who fulfilled the Rome criteria for FD enrolled in a randomized placebo-controlled trial (FD treatment trial), we examined construct validity, convergent validity, and internal consistency. Results: Construct validity was supported in its 25-item unweighted and weighted forms as well as the 10-item short form. All items in the 25-item form yielded considerable (>0.5) standardized loadings on their respective latent variables and all reached statistical significance (P<0.0001), supporting their relationships with the hypothesized domains. Convergent validity was strongly supported, with every domain being correlated with multiple external instruments; the majority of correlations were in the range 0.3-0.5 (in absolute values). The items comprising each domain showed good internal consistency, with the lowest value of Chronbach α at 0.80. Scores based on the short form (10-item) version of the NDI correlated strongly with the full 25-item form (tension ρ=0.88, interference ρ=0.94, eat/drink ρ=0.95, knowledge ρ=0.84 and work/study ρ=0.97; all P<0.0001). Conclusion: The NDI is a valid instrument that can be used to measure the disease-specific impact of FD on quality of life.
- Subject
- functional dyspepsia; psychometric properties; quality of life; symptom recording
- Identifier
- http://hdl.handle.net/1959.13/1409980
- Identifier
- uon:36103
- Identifier
- ISSN:0954-691X
- Language
- eng
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