- Title
- Laxative use in inpatients on oxycodone/naloxone prolonged release and oxycodone prolonged release for cancer and non-cancer pain
- Creator
- Patel, Joanne; Lucas, Catherine J.; Margalit, Maxwell; Martin, Jennifer H.
- Relation
- Journal of Pain & Palliative Care Pharmacotherapy Vol. 32, Issue 2-3, p. 116-123
- Publisher Link
- http://dx.doi.org/10.1080/15360288.2018.1545725
- Publisher
- Taylor & Francis
- Resource Type
- journal article
- Date
- 2018
- Description
- Objective: To examine the laxative prescriptions in hospital inpatients with cancer and non-cancer pain on oxycodone compared to oxycodone plus naloxone combination. Design: Retrospective case note review. Setting: A palliative care inpatient unit and a general medical ward in a large tertiary referral hospital. Participants: Eighty-four patients receiving oxycodone or combination oxycodone/naloxone on general medical (45 patients) and palliative care wards (39 patients). Main outcome measures: The primary recorded outcomes were regular opioid dose (milligrams per day) and number of prescribed laxatives (type, doses, and frequency per day). Results: Sixty-three (75%) patients in the study were on at least one laxative. In the general medicine inpatients, those on combined oxycodone/naloxone received on average 3.7 laxative doses per day compared to the oxycodone patients receiving 1.6 doses a day. In the palliative medicine population, both groups received a similar number of laxatives, despite the oxycodone/naloxone patients being on lower opioid doses. Conclusion: This retrospective study of hospital inpatients with cancer and non-cancer pain found that laxative use was not reduced in those on combined oxycodone/naloxone compared to oxycodone alone, suggesting that despite the interpretations of the clinical trials in the phase IV setting, the addition of naloxone had no effect on reducing laxative use.
- Subject
- oxycodone; constipation; laxatives; pain; naloxone
- Identifier
- http://hdl.handle.net/1959.13/1404697
- Identifier
- uon:35390
- Identifier
- ISSN:1536-0288
- Language
- eng
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