- Title
- Investigating the role of microparticles/ microvesicles/extracellular vesicles in vascular biology, haemostasis and haemopoietic dysregulation
- Creator
- Enjeti, Anoop K.
- Relation
- University of Newcastle Research Higher Degree Thesis
- Resource Type
- thesis
- Date
- 2019
- Description
- Research Doctorate - Doctor of Philosophy (PhD)
- Description
- The detection/enumeration method is key in determining microvesicle (MV) number and function. A combination of different techniques would be important to evaluate various facets of MV. The levels and function of MV vary with age, gender, blood counts, lipid/hormone profile and smoking status. Further, the levels and/or function of MV in certain pathological states (such as factor V Leiden and snake bites) influence thrombosis and/or bleeding. Finally, levels and functional haemostatic role of MV and its small RNA cargo are important in clonal bone marrow disorders such as Myelodysplasia and could be associated with clinical phenotype.
- Subject
- microvesicles; microparticles; myelodysplasia; miRNA; thesis by publication; extracellular vesicles; normal ranges; flow cytometry; nanotracking; tunable resistive pulse sensing; venous thromboembolism; factor V Leiden; snake envenoming
- Identifier
- http://hdl.handle.net/1959.13/1401157
- Identifier
- uon:34877
- Rights
- Copyright 2019 Anoop K. Enjeti
- Language
- eng
- Full Text
- Hits: 1860
- Visitors: 2582
- Downloads: 932
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Thesis | 6 MB | Adobe Acrobat PDF | View Details Download | ||
| View Details Download | ATTACHMENT02 | Abstract | 346 KB | Adobe Acrobat PDF | View Details Download |