- Title
- An in vitro investigation of cytotoxic effects of InP/Zns quantum dots with different surface chemistries
- Creator
- Ayupova, Deanna; Dobhal, Garima; Laufersky, Geoffry; Nann, Thomas; Goreham, Renee V.
- Relation
- Nanomaterials Vol. 9, Issue 2, no. 135
- Publisher Link
- http://dx.doi.org/10.3390/nano9020135
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2019
- Description
- Indium phosphide quantum dots (QDs) passivated with zinc sulphide in a core/shell architecture (InP/ZnS) with different surface chemistries were introduced to RAW 264.7 murine "macrophage-like" cells to understand their potential toxicities. The InP/ZnS quantum dots were conjugated with an oligonucleotide, a carboxylic acid, or an amino-polyethylene glycol ligand, and cell viability and cell proliferation were investigated via a metabolic assay. Membrane integrity was measured through the production of lactate dehydrogenase. Fluorescence microscopy showed cellular uptake. All quantum dots exhibited cytotoxic behaviour less than that observed from cadmium- or lead-based quantum dots; however, this behaviour was sensitive to the ligands used. In particular, the amino-polyethylene glycol conjugated quantum dots proved to possess the highest cytotoxicity examined here. This provides quantitative evidence that aqueous InP/ZnS quantum dots can offer a safer alternative for bioimaging or in therapeutic applications.
- Subject
- quantum yields; aptamer; photoluminescence; cytotoxicity; quantum dots; bioimaging
- Identifier
- http://hdl.handle.net/1959.13/1400646
- Identifier
- uon:34794
- Identifier
- ISSN:2079-4991
- Rights
- © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 2 MB | Adobe Acrobat PDF | View Details Download |