- Title
- Sputum basophils are increased in eosinophilic asthma compared with non-eosinophilic asthma phenotypes
- Creator
- Brooks, C. R.; van Dalen, C. J.; Hermans, I. F.; Gibson, P. G.; Simpson, J. L.; Douwes, J.
- Relation
- Allergy Vol. 72, Issue 10, p. 1583-1586
- Publisher Link
- http://dx.doi.org/10.1111/all.13185
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2017
- Description
- Sputum basophil numbers are increased in allergic asthmatics, but it is unclear what role airway basophils play in "TH2-low" asthma phenotypes. Using flow cytometry, we found that basophils were significantly increased in all asthmatics (n=26) compared with healthy controls (n=8) (P=0.007) with highest levels observed in eosinophilic asthma (EA); median 0.22%, IQR 0.11%-0.47%; n=14) compared with non-EA (NEA) (0.06%, 0.00%-0.20%; n=12; P < 0.05). In asthmatics, basophils were positively correlated with sputum eosinophils (r=0.54; P < 0.005) and inversely with sputum neutrophils (r=-0.46: P < 0.05), but not with FEV 1 (% predicted), FEV₁ /FVC or bronchodilator reversibility. In a subgroup initially identified as inadequately controlled asthma (n=7), there was a trend (P=0.08) towards a reduction in sputum basophils following increased inhaled corticosteroid (ICS) treatment. Our findings suggest that basophils may be particularly important in eosinophilic asthma and that sputum basophil assessment could be a useful additional indicator of "TH2-high" asthma.
- Subject
- asthma; basophil; biomarker; eosinophil; cytometry
- Identifier
- http://hdl.handle.net/1959.13/1400097
- Identifier
- uon:34729
- Identifier
- ISSN:0105-4538
- Language
- eng
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