Purinergic modulation of glutamate transmission: an expanding role in stress-linked neuropathology

Mayhew, J.; Graham, B. A.; Biber, K.; Nilsson, M.; Walker, F. R.

Title: Purinergic modulation of glutamate transmission: an expanding role in stress-linked neuropathology
Creator: Mayhew, J.; Graham, B. A.; Biber, K.; Nilsson, M.; Walker, F. R.
Relation: Neuroscience & Biobehavioral Reviews Vol. 93, Issue October 2018, p. 26-37
Publisher Link: http://dx.doi.org/10.1016/j.neubiorev.2018.06.023
Publisher: Pergamon Press
Resource Type: journal article
Date: 2018
Description: Chronic stress has been extensively linked to disturbances in glutamatergic signalling. Emerging from this field of research is a considerable number of studies identifying the ability of purines at the pre-, post-, and peri-synaptic levels to tune glutamatergic neurotransmission. While the evidence describing purinergic control of glutamate has continued to grow, there has been relatively little attention given to how chronic stress modulates purinergic functions. The available research on this topic has demonstrated that chronic stress can not only disturb purinergic receptors involved in the regulation of glutamate neurotransmission, but also perturb glial-dependent purinergic signalling. This review will provide a detailed examining of the complex literature relating to glutamatergic-purinergic interactions with a focus on both neuronal and glial contributions. Once these detailed interactions have been described and contextualised, we will integrate recent findings from the field of stress research.
Subject: purines; glutamate; neurotransmission; chronic stress
Identifier: http://hdl.handle.net/1959.13/1398947
Identifier: uon:34503
Identifier: ISSN:0149-7634
Language: eng
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