- Title
- An experimental model of hypersensitivity pneumonitis (extrinsic allergic alveolitis)
- Creator
- Bhagwandeen, S. B.; Pang, G. T.; Clancy, R. L.
- Relation
- 34th Annual Scientific Meeting of the Royal College of Pathologists of Australasia . Abstracts of Presentations at the 34th Annual Scientific Meeting of the Royal College of Pathologists of Australasia [presented in Pathology, Vol. 22, Suppl. 1] (Hong Kong 04-08 September, 1989) p. 35
- Publisher Link
- http://dx.doi.org/10.3109/00313029009060113
- Publisher
- Lippincott, Williams & Wilkins
- Resource Type
- conference paper
- Date
- 1990
- Description
- We describe an animal model in which Hypersensitivity Pneumonitis developed after exposure to a bacterial antigen. 50ul of a 24 hour nutrient broth culture containing 10¹⁰ cfu/ml of Pasturella pneumotropica were inoculated intratracheally into 8 - 12 week old pathogen free Brown Norway rats fed a standard laboratory chow diet. Control rats were inoculated with nutrient broth only. Rats (3 test and 2 control) were killed at 0, 4, 8 , 24 and 48 hours, 6 days and 10 days after inoculation. Lung showed progression of interstitial pneumonia from early lesions (24 and 48 hours) of interstitial subacute inflammatory cellular infiltrate centred around bronchioles to later lesions (6 and 10 days) with bronchiolitis obliterans and typical granulomatous lesions. Vasculitis was not seen. The pattern of pathology is identical with human HP. Our rat model, unlike several other models previously described, did not require pre-immunisation before challenge. Moreover we believe this is the first time that HP has been described following bacterial colonisation. Our model might prove useful for the study of immunopathogenesis of HP.
- Subject
- alveolitis; experimental; animal; pathology
- Identifier
- http://hdl.handle.net/1959.13/1397244
- Identifier
- uon:34221
- Identifier
- ISSN:0031-3025
- Language
- eng
- Reviewed
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