Morphometric analysis of coronary artery stenosis: an accuracy and reliability study

Title: Morphometric analysis of coronary artery stenosis: an accuracy and reliability study
Creator: Manwarring, Lynette; O'Connell, Dianne L.; Bhagwandeen, Brumdutt S.; Zardawi, Ibrahim M.
Relation: Journal of Pathology Vol. 156, Issue 2, p. 111-117
Publisher Link: http://dx.doi.org/10.1002/path.1711560205
Publisher: John Wiley & Sons
Resource Type: journal article
Date: 1988
Description: Luminal narrowing was assessed in 238 transverse segments obtained from coronary arteries removed at postmortem. In each segment, narrowing was assessed by gross visual estimation before and after fixation, and on histological sections by stereological point counting and computer‐assisted planimetry. Computer‐assisted planimetry was found to be accurate and reliable but the equipment needed is expensive, and requires specialized software and an experienced user. Morphometric measurement by stereologic point counting was accurate, rapid, simple, and inexpensive. In comparison with computer‐assisted planimetry visual estimation was found to be neither accurate nor reliable. Our results indicate point counting as the method of choice for assessment of coronary artery luminal narrowing by atherosclerosis.
Subject: visual estimation; coronary artery stenosis; morphometry; stereologic point counting
Identifier: http://hdl.handle.net/1959.13/1397183
Identifier: uon:34207
Identifier: ISSN:1096-9896
Language: eng
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