- Title
- Growth hormone deficiency is frequent after recent stroke
- Creator
- Lillicrap, Thomas; Garcia-Esperon, Carlos; Walker, Frederick Rohan; Ong, Lin Kooi; Nilsson, Michael; Spratt, Neil; Levi, Christopher R.; Parsons, Mark; Isgaard, Jörgen; Bivard, Andrew
- Relation
- Frontiers in Neurology Vol. 9, no. 713
- Publisher Link
- http://dx.doi.org/10.3389/fneur.2018.00713
- Publisher
- Frontiers Research Foundation
- Resource Type
- journal article
- Date
- 2018
- Description
- Introduction: The incidence of pituitary dysfunction after severe ischemic stroke is unknown, however given the increasing attention to pituitary dysfunction after neurological injuries such as traumatic brain injury, this may represent a novel area of research in stroke. Methods: We perform an arginine and human growth hormone releasing hormone challenge on ischemic stroke patients within a week of symptom onset. Results: Over the study period, 13 patients were successfully tested within a week of stroke (baseline NIHSS 10, range 7–16). Overall, 9(69%) patients had a poor response, with 7(54%) of these patients meeting the criteria for had human growth hormone deficiency. Other measures of pituitary function were within normal ranges. Conclusion: After major ischemic stroke, low GH levels are common and may play a role in stroke recovery.
- Subject
- hormone deficiency; stroke; severe ischemic stroke; pituitary dysfunction; neurological injuries; traumatic brain injury
- Identifier
- http://hdl.handle.net/1959.13/1394598
- Identifier
- uon:33725
- Identifier
- ISSN:1664-2295
- Rights
- Copyright © 2018 Lillicrap, Garcia-Esperon, Walker, Ong, Nilsson, Spratt, Levi, Parsons, Isgaard and Bivard. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Language
- eng
- Full Text
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