- Title
- Genetics and other risk factors for past concussions in active-duty soldiers
- Creator
- Dretsch, Michael N.; Silverberg, Noah; Iverson, Grant L.; Gardner, Andrew J.; Panenka, William J.; Emmerich, Tanja; Crynen, Gogce; Ait-Ghezala, Ghania; Chaytow, Helena; Mathura, Venkat; Crawford, Fiona C.
- Relation
- Journal of Neurotrauma Vol. 34, Issue 4, p. 869-875
- Publisher Link
- http://dx.doi.org/10.1089/neu.2016.4480
- Publisher
- Mary Ann Liebert
- Resource Type
- journal article
- Date
- 2017
- Description
- Risk factors for concussion in active-duty military service members are poorly understood. The present study examined the association between self-reported concussion history and genetics (apolipoprotein E [APOE], brain-derived neurotrophic factor [BDNF], and D2 dopamine receptor genes [DRD2]), trait personality measures (impulsive-sensation seeking and trait aggression-hostility), and current alcohol use. The sample included 458 soldiers who were preparing to deploy for Operation Iraqi Freedom/Operation Enduring Freedom. For those with the BDNF Met/Met genotype, 57.9% (11/19) had a history of one or more prior concussions, compared with 35.6% (154/432) of those with other BDNF genotypes (p = 0.049, odds ratio [OR] = 2.48). APOE and DRD2 genotypes were not associated with risk for past concussions. Those with the BDNF Met/Met genotype also reported greater aggression and hostility personality characteristics. When combined in a predictive model, prior military deployments, being male, and having the BDNF Met/Met genotype were independently associated with increased lifetime history of concussions in active-duty soldiers. Replication in larger independent samples is necessary to have more confidence in both the positive and negative genetic associations reported in this study.
- Subject
- APOE; BDNF; concussion; DRD2; genetics; mild traumatic brain injury; military; personality
- Identifier
- http://hdl.handle.net/1959.13/1390791
- Identifier
- uon:33133
- Identifier
- ISSN:0897-7151
- Language
- eng
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