- Title
- Improvement of the omega 3 index of healthy subjects does not alter the effects of dietary saturated fats or n-6PUFA on LDL profiles
- Creator
- Dias, Cintia B.; Amigó, Núria; Wood, Lisa G.; Mallol, Roger; Correig, Xavier; Garg, Manohar L.
- Relation
- Metabolism: Clinical and Experimental Vol. 68, p. 11-19
- Publisher Link
- http://dx.doi.org/10.1016/j.metabol.2016.11.014
- Publisher
- W.B. Saunders
- Resource Type
- journal article
- Date
- 2017
- Description
- Background and Aims. Dietary fat composition is known to modulate circulating lipid and lipoprotein levels. Although supplementation with long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to reduce plasma triglyceride levels, the effect of the interactions between LCn-3PUFA and the major dietary fats consumed has not been previously investigated. Methods: In a randomized controlled parallel design clinical intervention, we examined the effect of diets rich in either saturated fatty acids (SFA) or omega-6 polyunsaturated fatty acids (n-6PUFA) on plasma lipid levels and lipoprotein profiles (lipoprotein size, concentration and distribution in subclasses) in subjects with an adequate omega 3 index. Twenty six healthy subjects went through a four-week pre-supplementation period with LCn-3PUFA and were then randomized to diets rich in either n-6PUFA or SFA both supplemented with LCn-3PUFA. Results. The diet rich in n-6PUFA decreased low density lipoprotein (LDL) particle concentration (-8%, p=0.013) and LDL cholesterol (LDL-C) level (-8%, p=0.021), while the saturated fat rich diet did not affect LDL particle concentration or LDL-C levels significantly. Nevertheless, dietary saturated fatty acids increased LCn-3PUFA in plasma and tissue lipids compared with n-6PUFA, potentially reducing other cardiovascular risk factors such as inflammation and clotting tendency. Conclusion Improvement on the omega 3 index of healthy subjects did not alter the known effects of dietary saturated fats and n-6PUFA on LDL profiles.
- Subject
- lipids; omega 3; saturated fatty acids; polyunsaturated fatty acids; nuclear magnetic resonance spectroscopy; lipoprotein profiles
- Identifier
- http://hdl.handle.net/1959.13/1387976
- Identifier
- uon:32707
- Identifier
- ISSN:0026-0495
- Language
- eng
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