- Title
- Prevalence of clinically actionable genotypes and medication exposure of older adults in the community
- Creator
- Daneshi, Nilofar; Holliday, Elizabeth; Hancock, Stephen; Schneider, Jennifer J.; Scott, Rodney J.; Attia, John; Milward, Elizabeth A.
- Relation
- Pharmacogenomics and Personalized Medicine Vol. 10, p. 17-27
- Publisher Link
- http://dx.doi.org/10.2147/PGPM.S123719
- Publisher
- Dove Medical Press
- Resource Type
- journal article
- Date
- 2017
- Description
- This study analyzed clinically actionable pharmacogenotypes for clopidogrel, warfarin, statins, thiopurines, and tacrolimus using microarray data for 2121 participants (55-85 years) from the Australian Hunter Community Study (HCS). At least 74% of participants (95% confidence interval [CI]: 72%-76%) had strong level evidence for at least one medium- or high-risk actionable genotype that would trigger a change in standard therapy under current international recommendations. About 14% of these participants (95% CI: 12%-16%) were taking medication potentially affected by the genotype in question. Furthermore, ~2.6% of all participants with medication data (95% CI: 1.4%-3.8%) had a high-risk clinically actionable genotype for a medication to which they were exposed. This represents a considerable number of people at the population level. Although relationships between genotype and health outcomes remain contentious, pharmacogenotyping of multiple variants simultaneously may have considerable potential to improve medication safety and efficacy for older people in the community.
- Subject
- actionable genotype; community; older adults; pharmacogenomics; pre-emptive genotyping; single-nucleotide polymorphism
- Identifier
- http://hdl.handle.net/1959.13/1387984
- Identifier
- uon:32706
- Identifier
- ISSN:1178-7066
- Rights
- © 2017 Daneshi et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
- Language
- eng
- Full Text
- Reviewed
- Hits: 8537
- Visitors: 3336
- Downloads: 451
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 244 KB | Adobe Acrobat PDF | View Details Download |