- Title
- Green chemistry approaches to the Knoevenagel condensation: comparison of ethanol, water and solvent free (dry grind) approaches
- Creator
- McCluskey, Adam; Robinson, Philip J.; Hill, Tim; Scott, Janet L.; Edwards, J. Kate
- Relation
- Tetrahedron Letters Vol. 43, Issue 17, p. 3117-3120
- Publisher Link
- http://dx.doi.org/10.1016/S0040-4039(02)00480-X
- Publisher
- Elsevier Science Ltd.
- Resource Type
- journal article
- Date
- 2002
- Description
- We report a comparative study of the Knoevenagel condensation with a variety of substituted benzaldehydes (17 examples) and cyanoamides (3 examples), using three different methodologies: (a) traditional ethanol reflux; (b) water reflux; and (c) solvent free conditions. Almost without exception these reactions proceeded faster, more cleanly and in higher yields when the reactions were conducted in a solvent-free fashion. Additionally, our solvent free approach allowed the use of nitrobenzaldehydes, which failed to yield the desired products under traditional and water based approaches.
- Subject
- Green chemistry; solvent free; Knoevenagel condensations
- Identifier
- http://hdl.handle.net/1959.13/33615
- Identifier
- uon:3268
- Identifier
- ISSN:0040-4039
- Language
- eng
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