- Title
- Identification of aminopyrimidine regioisomers via line broadening effects in ¹H and ¹³C NMR spectroscopy
- Creator
- Garner, James; Hill, Tim; Odell, Luke; Keller, Paul; Morgan, Jody; McCluskey, Adam
- Relation
- Australian Journal of Chemistry Vol. 57, Issue 11, p. 1079-1083
- Publisher Link
- http://dx.doi.org/10.1071/CH03316
- Publisher
- CSIRO Publishing
- Resource Type
- journal article
- Date
- 2004
- Description
- Substituted mono- and diamino-pyrimidines were synthesized as part of our medicinal chemistry programmes. Primary amines substituted at the 4-position exhibited room-temperature line broadening effects in both ¹H and ¹³C NMR spectroscopy due to the presence of rotamers, but these effects were not observed for substituents in the 2-position. This provided a simple diagnostic tool for the identification of regioisomers, a determination which would otherwise have required two-dimensional experiments.
- Subject
- mono-pyrimidines; diamino-pyrimidines; amines; ¹H and ¹³C NMR spectroscopy; regioisomers
- Identifier
- http://hdl.handle.net/1959.13/33618
- Identifier
- uon:3267
- Identifier
- ISSN:0004-9425
- Language
- eng
- Reviewed
- Hits: 8707
- Visitors: 5959
- Downloads: 0
Thumbnail | File | Description | Size | Format |
---|