- Title
- Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and ⁹⁹ᵐTc-tetrofosmin: method and validation
- Creator
- Shrestha, Uttam; Sciammarella, Maria; Alhassen, Fares; Yeghiazarians, Yerem; Ellin, Justin; Verdin, Emily; Boyle, Andrew; Seo, Youngho; Botvinick, Elias H.; Gullberg, Grant T.
- Relation
- Journal of Nuclear Cardiology Vol. 24, Issue 1, p. 268-277
- Publisher Link
- http://dx.doi.org/10.1007/s12350-015-0320-3
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2017
- Description
- Background: The objective of this study was to measure myocardial blood flow (MBF) in humans using ⁹⁹ᵐTc-tetrofosmin and dynamic single-photon emission computed tomography (SPECT). Methods: Dynamic SPECT using ⁹⁹ᵐTc-tetrofosmin and dynamic positron emission tomography (PET) was performed on a group of 16 patients. The SPECT data were reconstructed using a 4D-spatiotemporal iterative reconstruction method. The data corresponding to 9 patients were used to determine the flow-extraction curve for ⁹⁹ᵐTc-tefrofosmin while data from the remaining 7 patients were used for method validation. The nonlinear tracer correction parameters A and B for ⁹⁹ᵐTc-tefrofosmin were estimated for the 9 patients by fitting the flow-extraction curve K₁=F(1-Aexp(-B/F)) for K₁ values estimated with ⁹⁹ᵐTc-tefrofosmin using SPECT and MBF values estimated with ¹³N-NH₃ using PET. These parameters were then used to calculate MBF and coronary flow reserve (CFR) in three coronary territories (LAD, RCA, and LCX) using SPECT for an independent cohort of 7 patients. The results were then compared with that estimated with ¹³N-NH₃ PET. The flow-dependent permeability surface-area product (PS) for ⁹⁹ᵐTc-tefrofosmin was also estimated. Results: The estimated flow-extraction parameters for ⁹⁹ᵐTc-tefrofosmin were found to be A = 0.91 ± 0.11, B = 0.34 ± 0.20 (R² = 0.49). The range of MBF in LAD, RCA, and LCX was 0.44-3.81 mL/min/g. The MBF between PET and SPECT in the group of independent cohort of 7 patients showed statistically significant correlation, r = 0.71 (P < .001). However, the corresponding CFR correlation was moderate r = 0.39 yet statistically significant (P = .037). The PS for ⁹⁹ᵐTc-tefrofosmin was (0.019 ± 0.10)*MBF + (0.32 ± 0.16). Conclusions: Dynamic cardiac SPECT using ⁹⁹ᵐTc-tetrofosmin and a clinical two-headed SPECT/CT scanner can be a useful tool for estimation of MBF.
- Subject
- dynamic SPECT; myocardial blood flow quantification; tracer kinetics; ammonia PET
- Identifier
- http://hdl.handle.net/1959.13/1387351
- Identifier
- uon:32593
- Identifier
- ISSN:1071-3581
- Language
- eng
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