- Title
- Targeting the TSH receptor in thyroid cancer
- Creator
- Rowe, Christopher W.; Paul, Jonathan W.; Gedye, Craig; Tolosa, Jorge M.; Bendinelli, Cino; McGrath, Shaun; Smith, Roger
- Relation
- Endocrine-Related Cancer Vol. 24, Issue 6, p. R191-R202
- Publisher Link
- http://dx.doi.org/10.1530/ERC-17-0010
- Publisher
- BioScientifica
- Resource Type
- journal article
- Date
- 2017
- Description
- Recent advances in the arena of theranostics have necessitated a re-examining of previously established fields. The existing paradigm of therapeutic thyroid-stimulating hormone receptor (TSHR) targeting in the post-surgical management of differentiated thyroid cancer using levothyroxine and recombinant human thyroid-stimulating hormone (TSH) is well understood. However, in an era of personalized medicine, and with an increasing awareness of the risk profile of longstanding pharmacological hyperthyroidism, it is imperative clinicians understand the molecular basis and magnitude of benefit for individual patients. Furthermore, TSHR has been recently re-conceived as a selective target for residual metastatic thyroid cancer, with pilot data demonstrating effective targeting of nanoparticles to thyroid cancers using this receptor as a target. This review examines the evidence for TSHR signaling as an oncogenic pathway and assesses the evidence for ongoing TSHR expression in thyroid cancer metastases. Priorities for further research are highlighted.
- Subject
- thyroid cancer; TSH receptor; theranostics; targeted therapy
- Identifier
- http://hdl.handle.net/1959.13/1384521
- Identifier
- uon:32094
- Identifier
- ISSN:1351-0088
- Rights
- Disclaimer: this is not the definitive version of record of this article. This manuscript has been accepted for publication in Endocrine-Related Cancer, but the version presented here has not yet been copy-edited, formatted or proofed. Consequently, Bioscientifica accepts no responsibility for any errors or omissions it may contain. The definitive version is now freely available at http://dx.doi.org/10.1530/ERC-17-0010 (2017)
- Language
- eng
- Full Text
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