In situ chelation of Ca²⁺ in intracellular stores induces capacitative Ca²⁺ entry in bovine adrenal chromaffin cells

Title: In situ chelation of Ca²⁺ in intracellular stores induces capacitative Ca²⁺ entry in bovine adrenal chromaffin cells
Creator: Powis, David A.; Zerbes, Mariann
Relation: Annals of the New York Academy of Sciences Vol. 971, p. 150-152
Relation: http://www3.interscience.wiley.com/journal/120778404/abstract
Publisher: New York Academy of Sciences
Resource Type: journal article
Date: 2002
Description: Reduction of intracellular Ca²⁺ stores (by chelation with the EDTA structural analogue, TPEN) is itself a sufficient trigger of capacitative Ca²⁺ entry. TPEN may be a useful tool in studies to investigate the mechanism of capacitative Ca²⁺ entry, since potential confounders, such as changes in cytosolic Ca²⁺ and second messenger levels, are obviated and the use of pharmacological modifiers of SERCA pumps and Ca²⁺ release channels is avoided.
Subject: Ca²⁺ chelation; bovine adrenal chromaffin cells; TPEN; capacitative Ca²⁺ entry
Identifier: http://hdl.handle.net/1959.13/33268
Identifier: uon:3155
Identifier: ISSN:0077-8923
Language: eng
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