- Title
- Three-dimensional OCT based Guinea pig eye model: relating morphology and optics
- Creator
- Pérez-Merino, Pablo; Velasco-Ocana, Miriam; Martinez-Enriquez, Eduardo; Revuelta, Luis; McFadden, Sally A.; Marcos, Susana
- Relation
- Biomedical Optics Express Vol. 8, Issue 4, p. 2173-2184
- Publisher Link
- http://dx.doi.org/10.1364/BOE.8.002173
- Publisher
- Optical Society of America
- Resource Type
- journal article
- Date
- 2017
- Description
- Custom Spectral Optical Coherence Tomography (SOCT) provided with automatic quantification and distortion correction algorithms was used to measure the 3-D morphology in guinea pig eyes (n = 8, 30 days; n = 5, 40 days). Animals were measured awake in vivo under cyclopegia. Measurements showed low intraocular variability (<4% in corneal and anterior lens radii and <8% in the posterior lens radii, <1% interocular distances). The repeatability of the surface elevation was less than 2 µm. Surface astigmatism was the individual dominant term in all surfaces. Higher-order RMS surface elevation was largest in the posterior lens. Individual surface elevation Zernike terms correlated significantly across corneal and anterior lens surfaces. Higher-order-aberrations (except spherical aberration) were comparable with those predicted by OCT-based eye models.
- Subject
- 3-D morphology; eye; guinea pig; OCT
- Identifier
- http://hdl.handle.net/1959.13/1354604
- Identifier
- uon:31310
- Identifier
- ISSN:2156-7085
- Language
- eng
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