- Title
- Trauma and stem cells: biology and potential therapeutic implications
- Creator
- Thurairajah, Kabilan; Broadhead, Matthew L.; Balogh, Zsolt J.
- Relation
- International Journal of Molecular Sciences Vol. 18, Issue 3, no. 577
- Publisher Link
- http://dx.doi.org/10.3390/ijms18030577
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2017
- Description
- Trauma may cause irreversible tissue damage and loss of function despite current best practice. Healing is dependent both on the nature of the injury and the intrinsic biological capacity of those tissues for healing. Preclinical research has highlighted stem cell therapy as a potential avenue for improving outcomes for injuries with poor healing capacity. Additionally, trauma activates the immune system and alters stem cell behaviour. This paper reviews the current literature on stem cells and its relevance to trauma care. Emphasis is placed on understanding how stem cells respond to trauma and pertinent mechanisms that can be utilised to promote tissue healing. Research involving notable difficulties in trauma care such as fracture non-union, cartilage damage and trauma induced inflammation is discussed further.
- Subject
- trauma; stem cells; inflammation; DAMP; healing
- Identifier
- http://hdl.handle.net/1959.13/1351417
- Identifier
- uon:30704
- Identifier
- ISSN:1661-6596
- Rights
- © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
- Reviewed
- Hits: 1983
- Visitors: 2283
- Downloads: 358
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 1 MB | Adobe Acrobat PDF | View Details Download |