- Title
- Visibility of CT early ischemic change significantly associates with time from stroke onset to baseline scan
- Creator
- Gao, Jian
- Relation
- University of Newcastle Research Higher Degree Thesis
- Resource Type
- thesis
- Date
- 2017
- Description
- Masters Research - Master of Philosophy (MPhil)
- Description
- Background: Non-contrast brain computed tomography (NCCT) remains the most common imaging modality employed to select patients for thrombolytic therapy in acute ischemic stroke. The current study used the Alberta Stroke Program Early CT Score (ASPECTS) to identify early ischemic changes on brain NCCT imaging with the aim to investigate whether a relationship exists between time from symptoms onset to NCCT with the presence of early ischaemic change quantified by ASPECTS. Method: We studied 1,329 ischemic stroke patients who had NCCT within 8 hours of stroke onset. Patients were assessed to see if they had any ASPECTS lesion and if the rate of patients with a lesion increased with time using logistic regression. Results: 30% patients had an ASPECTS<10 within the first 3 hours from symptom onset. Within the first 3 hours, odds ratio for a CT change (ASPECTS<10) per minute of time was 1.00 with 95% confidence interval (0.99 to 1.00) (p=0.266). After 3 hours, there was a significant increase in odds of ASPECTS<10 with increasing time. The odds increased 1% (OR=1.01) per 1 minute of time with 95% confidence interval (1.00 to 1.01) (p=0.002). Conclusion: We have identified that prior to first 3 hours of stroke there was no effect of time on odds of CT ischemic change (ASPECTS<10); after the first 3 hours of stroke, the odds of a ASPECTS<10 increased with increasing time to CT scan. The occurrence of early ischemic change may be a marker of time from stroke onset rather than severity.
- Subject
- stroke; tomography; x-ray computed; time
- Identifier
- http://hdl.handle.net/1959.13/1349936
- Identifier
- uon:30461
- Rights
- Copyright 2017 Jian Gao
- Language
- eng
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| View Details Download | ATTACHMENT01 | Thesis | 1 MB | Adobe Acrobat PDF | View Details Download | ||
| View Details Download | ATTACHMENT02 | Abstract | 121 KB | Adobe Acrobat PDF | View Details Download |