- Title
- Role of ion channels in the sperm acrosome reaction
- Creator
- Beltrán, Carmen; Treviño, Claudia L.; Mata-Martínez, Esperanza; Chávez, Julio C.; Sánchez-Cárdenas, Claudia; Baker, Mark; Darszon, Alberto
- Relation
- Sperm Acrosome Biogenesis and Function During Fertilization p. 35-69
- Relation
- Advances in Anatomy Embryology and Cell Biology 220
- Publisher Link
- http://dx.doi.org/10.1007/978-3-319-30567-7_3
- Publisher
- Springer International
- Resource Type
- book chapter
- Date
- 2016
- Description
- The acrosome, a single membrane-delimited specialized organelle, overlies the nucleus of many sperm species. The sperm acrosome reaction (AR) involves fusion and vesiculation at multiple points of the outer acrosomal membrane and the overlying plasma membrane; it is triggered by physiological inducers from the female gamete, its vicinity, or by exposure to appropriate pharmacological stimuli. This unique, tightly regulated, irreversible, single but complex exocytotic process releases the acrosomal contents which include Ca2+ and enzymes, modifies membrane components, and exposes the inner acrosomal membrane to the extracellularmedium (Dan 1952;Yanagimachi 1994). Sperm–egg coat penetration, fusion with the eggs’ plasma membrane, and finally fertilization require the release and exposure of cell components resulting from this exocytotic process (Buffone et al. 2014; Okabe 2014; Vacquier et al. 2014).
- Subject
- acrosome reaction; sperm; plasma membrane; ionic channels
- Identifier
- http://hdl.handle.net/1959.13/1347626
- Identifier
- uon:30077
- Identifier
- ISBN:9783319305677
- Language
- eng
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