- Title
- Genes related with Alzheimer's disease: A comparison of evolutionary search, statistical and integer programming approaches
- Creator
- Moscato, Pablo; Berretta, Regina; Hourani, Mou'Ath; Mendes, Alexandre; Cotta, Carlos
- Relation
- 3rd European Workshop on Evolutionary Bioinformatics. Applications on Evolutionary Computing:EvoWorkkshops 2005: EvoBIO, EvoCOMNET, EvoHOT, EvoIASP, EvoMUSART, and EvoSTOC (Lausanne, Switzerland 30th March - 1st April, 2005) p. 84-94
- Relation
- http://evonet.lri.fr/eurogp2005/?page=evobio
- Publisher
- Springer Verlag
- Resource Type
- conference paper
- Date
- 2005
- Description
- Three different methodologies have been applied to microarray data from brains of Alzheimer diagnosed patients and healthy patients taken as control. A clear pattern of differential gene expression results which can be regarded as a molecular signature of the disease. The results show the complementarity of the different methodologies, suggesting that a unified approach may help to uncover complex genetic risk factors not currently discovered with a single method. We also compare the set of genes in these differential patterns with those already reported in the literature.
- Subject
- microarray data; Alzheimers; genetic risk factors
- Identifier
- uon:2992
- Identifier
- http://hdl.handle.net/1959.13/32320
- Identifier
- ISBN:9783540253372
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