- Title
- Can CT perfusion accurately assess infarct core?
- Creator
- Huynh, Dan C.; Parsons, Mark W.; Swartz, Rick; Symons, Sean; Aviv, Richard I.; Wintermark, Max; Vagal, Achala; d¿Esterre, Christopher D.; Vitorino, Rita; Efkehari, Daniel; Knight, Jesse; Huynh, Thien J.; Bivard, Andrew
- Relation
- Neurovascular Imaging Vol. 2, Issue 7
- Publisher Link
- http://dx.doi.org/10.1186/s40809-016-0018-1
- Publisher
- BioMed Central
- Resource Type
- journal article
- Date
- 2016
- Description
- Background: We sought to quantify CTP-derived infarct core applying previously published perfusion thresholds to multi-institutional CTP data to assess the margin of error for 25 mL and 70 mL critical volume thresholds using early DWI as a reference standard. Methods: 60 patients with acute ischemic stroke undergoing CTP and DWI within 6 and 24 h of symptom onset, respectively, were retrospectively analyzed from 3 tertiary care centers. CTP-derived infarct core was calculated using published thresholds for absolute and relative CBF and CBV in addition to manual CBV tracing. Using DWI as the reference standard, performance of CTP-derived measures of infarct core was assessed using co-registered voxel-by-voxel analysis and total infarct volume comparison. Volumes of each CTP infarct core estimate were compared against DWI to determine the degree of infarct core over or underestimation at the critical volumes of 25 mL and 70 mL. Results: Median core infarct volume was 10.8 mL. Mean CTP-derived infarct core volumes were similar to DWI for all CTP threshold methods to within ± 1 mL. CBV tracing demonstrated an overall significant core overestimation compared to DWI (p = 0.017). All CTP core volume estimations showed robust correlation with DWI (Pearson p-value < 0.001). As core volume increased, CTP demonstrated increased deviation from DWI. At the critical cut-offs of 25 mL and 70 mL, relative CBF demonstrated the best agreement with DWI for infarct core compared to the other CTP-derived measures of infarct core. Conclusion: Our study demonstrates close approximation between multiple CTP-derived measures of infarct core and DWI infarct volume, Especially relative CBF.
- Subject
- CT perfusion; infract core; brain; CBF
- Identifier
- http://hdl.handle.net/1959.13/1346255
- Identifier
- uon:29819
- Identifier
- ISSN:2055-5792
- Rights
- This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Language
- eng
- Full Text
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