- Title
- Superior hydrolytic DNA cleavage by a dinuclear copper(II) N4S4-donor complex compared with a mononuclear N2S2-donor close analogue
- Creator
- De, Iuliis Geoffry N.; Lawrance, Geoffrey A.; Fieuw-Makaroff, Sabine
- Relation
- Inorganic Chemistry Communications Vol. 3, p. 307-309
- Publisher Link
- http://dx.doi.org/10.1016/S1387-7003(00)00076-9
- Publisher
- Elsevier Science B.V.
- Resource Type
- journal article
- Date
- 2000
- Description
- The cleavage of plasmid DNA by a dinuclear copper(II) complex of 1,2,4,5-tetrakis(1′-amino-3′-thiabutyl)benzene is promoted significantly (rate constant of 3.3×10⁻⁵ s⁻¹ at pH 7.8 and 37℃) compared with the essentially inactive mononuclear copper(II) complex of the analogue 1,2-bis(1′-amino-3′-thiabutyl)benzene (rate constant <10⁻¹⁰ s⁻¹). This implies that the two copper ions in close proximity and acting synergetically are important in accelerating cleavage, and separate roles for the two coppers in the dimer are proposed.
- Subject
- DNA hydrolysis; catalysed cleavage; dicopper(II) complexes; aminothioether ligand
- Identifier
- uon:2960
- Identifier
- http://hdl.handle.net/1959.13/32229
- Identifier
- ISSN:1387-7003
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