- Title
- fMRI evidence of altered auditory temporal processing in schizophrenia
- Creator
- Budd, T. W.
- Relation
- Australasian Schizophrenia Conference 2006. Australasian Schizophrenia Conference: Poster Abstracts (Presented in Australian and New Zealand Journal of Psychiatry Vol. 40, Supp. 2) (Fremantle, WA 21–23 August, 2006) p. A135-A135
- Publisher Link
- http://dx.doi.org/10.1111/j.1440-1614.2006.01860.x
- Publisher
- Taylor & Francis
- Resource Type
- conference paper
- Date
- 2006
- Description
- AIMS/ACKGROUND: The aim of this study was to use psychoacoustic and fMRI techniques to examine auditory temporal processing deficits previously identified in ERP studies of schizophrenia. Psychophysical sinusoidal amplitude modulation (SAM) detection thresholds provide a relatively unambiguous measure of auditory temporal processing. Using a representative range of SAM rates, temporal modulation transfer functions (TMTFs) are derived to detect alterations in a listener’s ability to perceive temporal fluctuations in the sound envelope. Similarly, auditory fMRI provides neurophysiologically defined TMTFs as reflected in the sensitivity of the BOLD contrast to variations in SAM rate. METHODS: 14 individuals meeting diagnostic criteria for schizophrenia and 16 healthy controls participated in separate psychoacoustic and fMRI sessions. Perceptually and neurophysiologically defined TMTFs were measured using bandpass noise stimuli (0–6 kHz) for 7 SAM rates (4, 8, 16, 32, 64, 128 and 256 Hz). RESULTS: Analysis of the psychoacoustic TMTFs revealed significant SAM rate-specific reductions in TMTF thresholds in the schizophrenia group relative to controls. ROI-based fMRI parametric analyses revealed a significant reduction in BOLD activation extent in bilateral regions of auditory cortex for the schizophrenia group was consistent with the reduced sensitivity to SAM stimuli. No significant difference in the magnitude of BOLD activation between patients and controls. CONCLUSIONS: The results of this study suggest that fMRI measures of auditory temporal processing may provide a unique, in vivo measure of the integrity of auditory temporal processing in humans. The initial results also provide supporting evidence for temporal processing deficits in schizophrenia, suggesting that these alterations are greatest for temporal processing of amplitude modulated stimulation at rates higher than 32 Hz.
- Subject
- fMRI; schizophrenia; sinusoidal amplitude modulation; auditory temporal processing deficits; temporal modulation transfer functions
- Identifier
- uon:2959
- Identifier
- http://hdl.handle.net/1959.13/32228
- Identifier
- ISSN:0004-8674
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