- Title
- Short-term risk of cancer among women with previous gestational diabetes: a population-based study
- Creator
- Bejaimal, S. A. D.; Wu, C. F.; Lowe, J.; Feig, D. S.; Shah, B. R.; Lipscombe, L. L.
- Relation
- Diabetic Medicine Vol. 33, Issue 1, p. 39-46
- Publisher Link
- http://dx.doi.org/10.1111/dme.12796
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2016
- Description
- Aims: To evaluate the relationship between gestational diabetes (GDM) and incidence of cancer in women within the first decade postpartum. Methods: This population-based retrospective cohort study compared the risk of cancer in women with GDM with that of a matched control group comprising pregnant women without diabetes. We included women from Ontario, Canada aged 20-50 years with no history of cancer who had given birth between 1995 and 2008 (N = 149 049). Women with GDM (N = 49 684) were matched on age and year of giving birth, in a ratio of 1:2, to pregnant women without diabetes (N = 99 365). Results: Over a median 8-year follow-up, there were a total of 2927 (1.5%) cancers. After adjustment for covariates, we found no significant difference in overall risk of cancer between women with GDM and matched control subjects; however, GDM was associated with a significantly greater risk of thyroid cancer (adjusted hazard ratio 1.24, 95% CI 1.05, 1.46) and a significantly lower risk of premenopausal breast cancer (hazard ratio 0.86, 95% CI 0.75, 0.98) compared with matched control subjects. Conclusions: This large population-based study did not find a greater risk of cancers among women with GDM during the first decade postpartum; however, GDM was associated with a higher risk of thyroid cancer and a lower risk of premenopausal breast cancer. Further studies are needed to confirm these findings.
- Subject
- cancer; women; gestational diabetes; postpartum
- Identifier
- http://hdl.handle.net/1959.13/1343452
- Identifier
- uon:29173
- Identifier
- ISSN:0742-3071
- Language
- eng
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