- Title
- The effect of dietary supplementation of green tea catechins on cardiovascular disease risk markers in humans: a systematic review of cinical trials
- Creator
- Lau, Sarah O.; Georgousopoulou, Ekavi N.; Kellett, Jane; Thomas, Jackson; McKune, Andrew; Mellor, Duane; Roach, Paul D.; Naumovski, Nenad
- Relation
- Beverages Vol. 2, Issue 2, p. 16-16
- Publisher Link
- http://dx.doi.org/10.3390/beverages2020016
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2016
- Description
- Green tea catechins (GTCs) are secondary plant metabolites that have been associated with health benefits in human trials. As such, they have the potential to reduce cardiovascular disease (CVD) risk; however, results are not consistent. This systematic review of the published data assessed the putative effect of GTCs supplementation on anthropometric, blood pressure, and biochemical measures associated with CVD risk. It was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines exploring four major electronic databases (MEDLINE, Cochrane Library, Web of Science, and Scopus). Studies were included if they were published in peer-reviewed journals in English from 1990 until October 2015, and were human double-blind randomized and placebo-controlled trials (RCTs). From 122,428 articles initially identified, after two levels of screening, seven studies met the inclusion criteria. The review revealed consistent and significant (p ≤ 0.05) reductions in body mass index (BMI), blood pressure and plasma lipids; however, this effect would have been less if between-group effects had been considered. The current evidence base also has considerable methodological limitations due to suboptimal statistical methods used in data analyses. Future research efforts must aim to rectify this paucity of evidence with well-designed and well-reported prospective studies.
- Subject
- green tea catechins; GTCs; epigallocatechin gallate; EGCG; systematic review; human clinical trials; cardiovascular disease biomarkers
- Identifier
- http://hdl.handle.net/1959.13/1343222
- Identifier
- uon:29108
- Identifier
- ISSN:2306-5710
- Rights
- © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
- Reviewed
- Hits: 5107
- Visitors: 5254
- Downloads: 210
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 559 KB | Adobe Acrobat PDF | View Details Download |