- Title
- The relationship between the apolipoprotein E e4 allele and hippocampal MRI volume in community dwelling individuals with mild Alzheimer's disease
- Creator
- Walsh, Bernard; Slater, Stuart; Nair, Balakrishnan; Attia, John
- Relation
- Degenerative Neurological and Neuromuscular Disease Vol. 3, p. 11-14
- Publisher Link
- http://dx.doi.org/10.2147/DNND.S40835
- Publisher
- Dove Medical Press
- Resource Type
- journal article
- Date
- 2013
- Description
- Background: The degree of hippocampal magnetic resonance imaging (MRI) volume loss in Alzheimer's disease (AD) is commonly accepted as a marker of disease severity, yet remains expensive, unavailable, or not tolerated by many patients. Aim: To examine whether the presence of one or more apolipoprotein E (ApoE) e4 alleles is associated with smaller hippocampal MRI volumes in a population of early AD patients. Methods: A total of 88 consecutive patients attending a community-based memory disorders clinic who had both mild dementia on the Clinical Dementia Rating scale and Diagnostic and Statistical Manual of Mental Disorders criteria for probable AD were recruited. We examined the relationship between ApoE e4 allele load and hippocampal atrophy on MRI volumes. Results: There was no association between the ApoE e4 load and hippocampal volume in this cohort. Conclusion: This study suggests that the presence of one or more ApoE e4 alleles cannot be used to estimate pathological disease load in early AD.
- Subject
- apolipoprotein E; Alzheimer's disease; MRI; hippocampus
- Identifier
- http://hdl.handle.net/1959.13/1341172
- Identifier
- uon:28680
- Identifier
- ISSN:1179-9900
- Rights
- This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
- Language
- eng
- Full Text
- Reviewed
- Hits: 3112
- Visitors: 3682
- Downloads: 423
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 180 KB | Adobe Acrobat PDF | View Details Download |