- Title
- The association between chronic arsenic exposure and type 2 diabetes: a meta-analysis
- Creator
- Rahman, Bayzidur; Abir, Tanvir; Hossain, AKM Akbar; Islam, Md. Rafiqul; Milton, Abul Hasnat
- Relation
- Handbook of Arsenic Toxicology p. 557-573
- Publisher Link
- http://dx.doi.org/10.1016/B978-0-12-418688-0.00024-1
- Publisher
- Academic Press
- Resource Type
- book chapter
- Date
- 2015
- Description
- An association has been reported between chronic arsenic exposure and type 2 diabetes (T2D), although the evidence is still inconclusive. We incorporated 27 studies in the analysis including 15 cross-sectional, four case–control, and three cohort studies reporting OR, and three cross-sectional and two cohort studies reporting RR. The pooled OR estimate was 1.58 (95% CI: 1.35, 1.84), and the pooled RR was 1.28 (95% CI: 1.03, 1.59). The overall pooled estimate was 1.50 (95% CI: 1.33, 1.69). The between-study heterogeneity was high (I2=75.5%). We did not observe any significant dose–response association and there was no evidence of publication bias in this study. Overall, this meta-analysis suggests that chronic arsenic exposure is likely to increase the risk of T2D. However, this finding is limited by high between-study heterogeneity. Therefore, the hypothesized association needs further validation through well-conducted large prospective cohort studies with better exposure assessment.
- Subject
- arsenic; drinking water; type 2 diabetes; diabetes mellitus; meta-analysis
- Identifier
- http://hdl.handle.net/1959.13/1339482
- Identifier
- uon:28266
- Identifier
- ISBN:9780124186880
- Language
- eng
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