- Title
- Fat type in phytosterol products influence their cholesterol-lowering potential: a systematic review and meta-analysis of RCTs
- Creator
- Ferguson, Jessica J. A.; Stojanovski, Elizabeth; MacDonald-Wicks, Lesley; Garg, Manohar L.
- Relation
- Progress in Lipid Research Vol. 64, Issue October 2016, p. 16-29
- Publisher Link
- http://dx.doi.org/10.1016/j.plipres.2016.08.002
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2016
- Description
- The most common form of phytosterol (PS) fortified foods are fat spreads and dairy products. The predominant fats used are soybean/sunflower (SS) or rapeseed/canola (RC) oils and animal fat (D) in dairy products. This review aimed to investigate whether the carrier fat is a determinant of the hypocholesterolaemic effects of PS fortified foods. Databases were searched using relevant keywords and published RCTs from 1990 investigating the effects of dietary PS intervention (≥1.5 g per day) on total cholesterol and LDL-C were included. After methodological quality assessment and data extraction, a total of 32 RCTs (RC, n = 15; SS, n = 9; D, n = 8) were included. As expected, all fat groups significantly reduced TC and LDL-C (p<0.01). When compared across different carrier fats, RC as the main carrier fat, reduced LDL-C significantly more than the SS spreads (p=0.01). Therefore, a combination of monounsaturated fatty acid rich spread with adequate amounts of omega-3 fatty acids (as evident in RC spreads) may be the superior carrier fat for the delivery of PS for optimal blood cholesterol-lowering. The findings of this research provide useful evidence for optimising the hypocholesterolaemic effects of PS and support further investigation into the possible mechanisms behind these findings.
- Subject
- phyosterols; rapeseed; canola; sunflower; dairy; cholesterol
- Identifier
- http://hdl.handle.net/1959.13/1337972
- Identifier
- uon:27931
- Identifier
- ISSN:0163-7827
- Rights
- © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
- Language
- eng
- Full Text
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