Small molecule inhibitors of protein kinases in cancer: how to overcome resistance

Title: Small molecule inhibitors of protein kinases in cancer: how to overcome resistance
Creator: Griffith, R.; Brown, M. N.; McCluskey, A.; Ashman, L. K.
Relation: Mini-Reviews in Medicinal Chemistry Vol. 6, Issue 10, p. 1101-1110
Relation: http://www.bentham.org/mrmc/contabs/mrmc6-10.htm#5
Publisher: Bentham Science Publishers Ltd.
Resource Type: journal article
Date: 2006
Description: Small molecule protein kinase inhibitors show great promise as anti-cancer agents, however, de novo and acquired resistance present problems. These are reviewed and illustrated using the receptor tyrosine kinase, KIT, as an example. Emerging solutions are presented, such as targeting active kinase conformations.
Subject: small molecule protein kinase inhibitors; anti-cancer agents; de novo; receptor tyrosine kinase; KIT; active kinase conformations
Identifier: http://hdl.handle.net/1959.13/31726
Identifier: uon:2784
Identifier: ISSN:1389-5575
Language: eng
Reviewed

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