- Title
- Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2
- Creator
- Arima, Hisatomi; Heeley, Emma; Huang, Yining; Wang, Jigiang; Chalmers, John; Anderson, Craig S; Delcourt, Candice; Hirakawa, Yoichiro; Wang, Xia; Woodward, Mark; Robinson, Thompson; Stapf, Christian; Parsons, Mark; Lavados, Pablo M.
- Relation
- NHMRC.571281, NHMRC.512402 & NHMRC.1004170 http://purl.org/au-research/grants/nhmrc/571281
- Relation
- Neurology Vol. 84, Issue 5, p. 464-471
- Publisher Link
- http://dx.doi.org/10.1212/WNL.0000000000001205
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 2015
- Description
- Objectives: To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH). Methods: INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150-220 mm Hg) who were allocated to receive intensive (target SBP ,140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP ,180 mm Hg) BPlowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days. Results: Analysis of the randomized comparisons showed that intensive BP lowering produced comparable benefits on physical function at 90 days in 5 subgroups defined by baseline SBP of ,160, 160-169, 170-179, 180-189, and ≥190 mm Hg (p homogeneity 5 0.790). Analyses of achieved BP showed linear increases in the risk of physical dysfunction for achieved SBP above 130 mm Hg for both hyperacute (1-24 hours) and acute (2-7 days) phases while modest increases were also observed for achieved SBP below 130 mm Hg. Conclusions: Intensive BP lowering appears beneficial across a wide range of baseline SBP levels, and target SBP level of 130-139 mm Hg is likely to provide maximum benefit in acute ICH. Classification of evidence: This study provides Class I evidence that the effect of intensive BP lowering on physical function is not influenced by baseline BP.
- Subject
- blood pressure; blood pressure levels; acute intracerebral hemorrhage
- Identifier
- http://hdl.handle.net/1959.13/1337409
- Identifier
- uon:27845
- Identifier
- ISSN:0028-3878
- Language
- eng
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