- Title
- Vestibular system
- Creator
- Lim, Rebecca; Brichta, Alan M.
- Relation
- The Mouse Nervous System p. 661-678
- Publisher Link
- http://dx.doi.org/10.1016/b978-0-12-369497-3.10023-8
- Publisher
- Elsevier
- Resource Type
- book chapter
- Date
- 2012
- Description
- There are many excellent reviews on the mammalian vestibular system, however, none have focused primarily on mice. And yet now is a golden age for studies on the mouse vestibular system, evidenced by the burgeoning literature that ranges from molecular development of vestibular peripheral organs to central processing of vestibular-mediated behavior. As mentioned in other chapters, this rapid growth of knowledge is due in large part to mice being firmly established as the preferred mammalian model for molecular and genetic studies. These animals have provided us with a bounty of unique insights about the form and function of inner ear systems, hearing and balance. For example, mutant and transgenic varieties of mice have been essential in helping us understand the molecular identity of various structures and mechanisms, such as the tip-link composition between the hair cell projections, as well as the role of several motor proteins, such as prestin and various myosins, in the transduction cascade (Friedman et al., 2009). Indeed, in some areas of research such as mouse vestibular organ development, we now have the most complete description of any mammalian vestibular system. While this chapter cannot possibly cover the entire field of the mouse vestibular system, it will attempt to highlight areas that have excited particular interest in recent years. Some of this information recapitulates that which has been previously described in larger mammals (including gerbils, rats, guinea pigs, chinchillas, cats, and monkeys) but as expected there are often subtle and some not so subtle differences. In summary, the mouse, while not the first or necessarily an ideal choice for the many avenues of vestibular research, is fast becoming one of the most thoroughly and broadly studied mammalian models of vestibular function.
- Subject
- vestibular system; mammalian vestibular system; mice
- Identifier
- http://hdl.handle.net/1959.13/1334215
- Identifier
- uon:27257
- Identifier
- ISBN:9780123694973
- Language
- eng
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