- Title
- Lower preoperative quality of life increases postoperative risk of adverse events in women with endometrial cancer: results from the LACE trial
- Creator
- Baker, Jannah; Janda, Monika; Gebski, Val; Forder, Peta; Hogg, Russell; Manolitsas, Tom; Obermair, Andreas
- Relation
- NHMRC.456110
- Relation
- Gynecologic Oncology Vol. 137, Issue 1, p. 102-105
- Publisher Link
- http://dx.doi.org/10.1016/j.ygyno.2015.02.008
- Publisher
- Academic Press
- Resource Type
- journal article
- Date
- 2015
- Description
- Objective: To examine the association between preoperative quality of life (QoL) and postoperative adverse events in women treated for endometrial cancer. Methods: 760 women with apparent Stage I endometrial cancer were randomised into a clinical trial evaluating laparoscopic versus open surgery. This analysis includes women with preoperative QoL measurements, from the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire, and who were followed up for at least 6 weeks after surgery (n= 684). The outcomes for this study were defined as (1) the occurrence of moderate to severe adverse events within 6 months (Common Toxicology Criteria (CTC) grade =3); and (2) any serious adverse event (SAE). The association between preoperative QoL and the occurrence of AE was examined, after controlling for baseline comorbidity and other factors. Results: After adjusting for other factors, odds of occurrence of AE of CTC grade =3 were significantly increased with each unit decrease in baseline FACT-G score (OR = 1.02, 95% CI 1.00-1.03, p = 0.030), which was driven by physical well-being (PWB) (OR = 1.09, 95% CI 1.04-1.13, p = 0.0002) and functional well-being subscales (FWB) (OR=1.04, 95% CI 1.00-1.07, p=0.035). Similarly, odds of SAE occurrence were significantly increased with each unit decrease in baseline FACT-G score (OR = 1.02, 95% CI 1.01-1.04, p = 0.011), baseline PWB (OR = 1.11, 95% CI 1.06-1.16, p < 0.0001) or baseline FWB subscales (OR = 1.05, 95% CI 1.01- 1.10, p = 0.0077). Conclusion: Women with early endometrial cancer presenting with lower QoL prior to surgery are at higher risk of developing a serious adverse event following surgery. Funding: Cancer Council Queensland, Cancer Council New South Wales, Cancer Council Victoria, Cancer Council, Western Australia; NHMRC project grant 456110; Cancer Australia project grant 631523; The Women and Infants Research Foundation, Western Australia; Royal Brisbane and Women's Hospital Foundation; Wesley Research Institute; Gallipoli Research Foundation; Gynetech; TYCO Healthcare, Australia; Johnson and Johnson Medical, Australia; Hunter New England Centre for Gynaecological Cancer; Genesis Oncology Trust; and Smart Health Research Grant QLD Health.
- Subject
- endometrial cancer; adverse events; complications; quality of life; randomised trial
- Identifier
- http://hdl.handle.net/1959.13/1334190
- Identifier
- uon:27255
- Identifier
- ISSN:0090-8258
- Language
- eng
- Reviewed
- Hits: 3480
- Visitors: 3440
- Downloads: 0
| Thumbnail | File | Description | Size | Format |
|---|