- Title
- Intracranial haemorrhages associated with venom induced consumption coagulopathy in Australian snakebites (ASP-21)
- Creator
- Berling, Ingrid; Brown, Simon G. A.; Miteff, Ferdi; Levi, Christopher; Isbister, Geoffrey K.
- Relation
- NHMRC.1055176, NHMRC.1061041 & NHMRC.1023265 http://purl.org/au-research/grants/nhmrc/1061041
- Relation
- Toxicon Vol. 102, Issue August 2015, p. 8-13
- Publisher Link
- http://dx.doi.org/10.1016/j.toxicon.2015.05.012
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2015
- Description
- Intracranial haemorrhage (ICH) is a rare life-threatening consequence of venom induced consumption coagulopathy in snake-bite. It is unclear why certain patients haemorrhage. We aimed to investigate ICH in snake envenoming. Cases of venom-induced consumption coagulopathy from July 2005-June 2014 were identified from the Australian Snakebite Project, a prospective multicentre cohort of snake-bites. Cases with venom-induced consumption coagulopathy were extracted with data on the snake-bite, clinical effects, laboratory investigations, treatment and outcomes. 552 cases had venom-induced consumption coagulopathy; median age, 40 y (2-87 y), 417 (76%) males, 253 (46%) from brown snakes and 17 died (3%). There were 6/552 (1%) cases of ICH; median age, 71 y (59-80 y), three males and five from brown snakes. All received antivenom and five died. All six had a history of hypertension. Time to onset of clinical effects consistent with ICH was 8-12 h in four cases, and within 3 h in two. Difficult to manage hypertension and vomiting were common. One patient had a normal cerebral CT on presentation and after the onset of focal neurological effects a repeat CT showed an ICH. ICH is rare in snake-bite with only 1% of patients with coagulopathy developing one. Older age and hypertension were associated with ICH.
- Subject
- snake envenoming; consumption coagulopathy; intracranial hemorrhages; snake bites; haemorrhage
- Identifier
- http://hdl.handle.net/1959.13/1334097
- Identifier
- uon:27224
- Identifier
- ISSN:0041-0101
- Language
- eng
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