- Title
- A potential role for N-acetylcysteine in the management of methamphetamine dependence (commentary)
- Creator
- McKetin, Rebecca; Dean, Olivia M.; Baker, Amanda L.; Carter, Greg; Turner, Alyna; Kelly, Peter J.; Berk, Michael
- Relation
- Drug and Alcohol Review Vol. 36, Issue 2, p. 153-159
- Publisher Link
- http://dx.doi.org/10.1111/dar.12414
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2017
- Description
- Methamphetamine dependence is a growing problem in Australia and globally. Currently, there are no approved pharmacotherapy options for the management of methamphetamine dependence. N-acetylcysteine is one potential pharmacotherapy option. It has received growing attention as a therapy for managing addictions because of its capacity to restore homeostasis to brain glutamate systems disrupted in addiction and thereby reduce craving and the risk of relapse. N-acetylcysteine also has antioxidant properties that protect against methamphetamine-induced toxicity and it may therefore assist in the management of the neuropsychiatric and neurocognitive effects of methamphetamine. This commentary overviews the actions of N-acetylcysteine and evidence for its efficacy in treating addiction with a particular focus on its potential utility for methamphetamine dependence. We conclude that the preliminary evidence indicates a need for full-scale trials to definitively establish whether N-acetylcysteine has a therapeutic benefit and the nature of this benefit, for managing methamphetamine dependence.
- Subject
- methamphetamine; treatment; pharmacotherapy; drug therapy; N-acetylcysteine
- Identifier
- http://hdl.handle.net/1959.13/1333204
- Identifier
- uon:27031
- Identifier
- ISSN:0959-5236
- Rights
- This is the peer reviewed version of the following article: McKetin, Rebecca; Dean, Olivia M.; Baker, Amanda L.; Carter, Greg; Turner, Alyna; Kelly, Peter J.; Berk, Michael; (2017), “A potential role for N-acetylcysteine in the management of methamphetamine dependence”, Drug and Alcohol Review, which has been published in final form at http://dx.doi.org/10.1111/dar.12414. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
- Language
- eng
- Full Text
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